Abstract
Human cytomegalovirus (HCMV) is a widespread human pathogen, possessing onco-modulatory properties. Constitutive signaling of the HCMV-encoded chemokine receptor US28 and its ability to bind a broad spectrum of chemokines might facilitate HCMV-associated tumor progression. Novel nonpeptidergic chemotypes were identified as neutral antagonists or inverse agonists on US28, that allosterically inhibit chemokine binding to US28.
Copyright 2009 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amines / chemical synthesis
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Amines / chemistry
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Amines / pharmacology*
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Humans
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Imipramine / analogs & derivatives
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Imipramine / chemistry
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Imipramine / pharmacology*
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Indenes / chemical synthesis
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Indenes / chemistry
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Indenes / pharmacology*
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Ligands
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Molecular Structure
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Receptors, Chemokine / agonists
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Receptors, Chemokine / antagonists & inhibitors*
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Structure-Activity Relationship
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Viral Proteins / agonists
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Viral Proteins / antagonists & inhibitors*
Substances
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2-(2,4-dichlorobenzyl)-2,3-dihydro-1H-inden-1-amine
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Amines
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Indenes
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Ligands
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Receptors, Chemokine
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US28 receptor, Cytomegalovirus
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Viral Proteins
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Imipramine