Synthesis of 3,6-branched oligomannoside fragments of the mannan from Candida albicans cell wall corresponding to the antigenic factor 4

Alexander A Karelin; Yury E Tsvetkov; Lucia Paulovicová; Slavomír Bystrický; Ema Paulovicová; Nikolay E Nifantiev

doi:10.1016/j.carres.2009.11.012

Synthesis of 3,6-branched oligomannoside fragments of the mannan from Candida albicans cell wall corresponding to the antigenic factor 4

Carbohydr Res. 2010 Jul 2;345(10):1283-90. doi: 10.1016/j.carres.2009.11.012. Epub 2009 Nov 12.

Authors

Alexander A Karelin¹, Yury E Tsvetkov, Lucia Paulovicová, Slavomír Bystrický, Ema Paulovicová, Nikolay E Nifantiev

Affiliation

¹ Laboratory of Glycoconjugate Chemistry, N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, 119991 Moscow, Russia.

PMID: 20096401
DOI: 10.1016/j.carres.2009.11.012

Abstract

3-Aminopropyl glycosides of 3,6-branched penta- and hexamannoside fragments of the cell wall mannan from Candida albicans, corresponding to the antigenic factor 4, have been synthesized. Subsequent coupling of both oligosaccharides with BSA using the squarate procedure provided corresponding neoglycoconjugates.

MeSH terms

Animals
Antigens, Fungal / chemistry*
Antigens, Fungal / immunology
Candida albicans / cytology*
Candida albicans / immunology*
Carbohydrate Sequence
Cattle
Cell Wall / chemistry*
Epitopes / chemistry
Epitopes / immunology
Glycosides / chemistry
Mannans / chemistry*
Mannans / immunology
Molecular Sequence Data
Oligosaccharides / chemical synthesis*
Oligosaccharides / chemistry*
Oligosaccharides / metabolism
Serum Albumin, Bovine / metabolism

Substances

Antigens, Fungal
Epitopes
Glycosides
Mannans
Oligosaccharides
oligomannoside
Serum Albumin, Bovine