In-vivo analgesic and anti-inflammatory activities of newly synthesized benzimidazole derivatives

Eur J Med Chem. 2010 May;45(5):2048-54. doi: 10.1016/j.ejmech.2010.01.029. Epub 2010 Jan 21.

Abstract

A series of 2-methylaminobenzimidazole derivatives (1-11) were synthesized by the reaction of 2-(chloromethyl)-1H-benzimidazole derivatives with primary aromatic amines. All these compounds were characterized by IR, 1H NMR, 13C NMR, GC-MS and elemental analysis. The newly synthesized compounds were screened for analgesic and anti-inflammatory activities on acetic acid induced writhing in mice and carrageenan induced paw oedema in rats. Compounds (7) and (2) showed a potent analgesic (89% at 100 mg/kg b.w) and anti-inflammatory (100% at 100 mg/kg b.w) activities compared with standard drug Nimesulide (100% at 50 mg/kg b.w) respectively. The other compounds showed good analgesic and anti-inflammatory activities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetic Acid
  • Analgesics / chemical synthesis
  • Analgesics / chemistry
  • Analgesics / pharmacology*
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Benzimidazoles / chemical synthesis
  • Benzimidazoles / chemistry
  • Benzimidazoles / pharmacology*
  • Carrageenan
  • Drug Evaluation, Preclinical
  • Edema / chemically induced
  • Edema / drug therapy*
  • Mice
  • Molecular Structure
  • Pain / chemically induced
  • Pain / drug therapy*
  • Pain Measurement
  • Rats
  • Stereoisomerism
  • Structure-Activity Relationship

Substances

  • Analgesics
  • Anti-Inflammatory Agents, Non-Steroidal
  • Benzimidazoles
  • Carrageenan
  • benzimidazole
  • Acetic Acid