Realistic modeling approaches of structure-function properties of CPPs in non-covalent complexes

Annick Thomas; Laurence Lins; Gilles Divita; Robert Brasseur

doi:10.1016/j.bbamem.2010.02.020

Realistic modeling approaches of structure-function properties of CPPs in non-covalent complexes

Biochim Biophys Acta. 2010 Dec;1798(12):2217-22. doi: 10.1016/j.bbamem.2010.02.020. Epub 2010 Feb 23.

Authors

Annick Thomas¹, Laurence Lins, Gilles Divita, Robert Brasseur

Affiliation

¹ Gembloux AgroBiotech, ULg, 2 passage des déportés 5030 Gembloux, Belgium. athomas@ulg.ac.be

PMID: 20188064
DOI: 10.1016/j.bbamem.2010.02.020

Abstract

Transfers of cargoes into cells by means of carrier peptides are multi-steps biological phenomenon the mechanisms of which are unclear. We here discuss bases of realistic in silico molecular modeling approaches of the formation of non-covalent complexes considering CPPs and cargo diversities.

Publication types

Review

MeSH terms

Animals
Cell-Penetrating Peptides / chemistry*
Computer Simulation*
Humans
Models, Molecular*
Structure-Activity Relationship

Substances

Cell-Penetrating Peptides