Design and synthesis of active vitamin D analogs

Silvina Eduardo-Canosa; Ramón Fraga; Rita Sigüeiro; Maria Marco; Natacha Rochel; Dino Moras; Antonio Mouriño

doi:10.1016/j.jsbmb.2010.03.036

Design and synthesis of active vitamin D analogs

J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):7-12. doi: 10.1016/j.jsbmb.2010.03.036. Epub 2010 Mar 24.

Authors

Silvina Eduardo-Canosa¹, Ramón Fraga, Rita Sigüeiro, Maria Marco, Natacha Rochel, Dino Moras, Antonio Mouriño

Affiliation

¹ Departamento de Química Orgánica y Unidad Asociada al C.S.I.C., Universidad de Santiago de Compostela, E-15706 Santiago de Compostela, Spain.

PMID: 20346396
DOI: 10.1016/j.jsbmb.2010.03.036

Abstract

A review of the design and synthesis of structural analogs of the vitamin D hormone recently investigated in our laboratories, and the first report on a new class of vitamin D analogs characterized by an aromatic D-ring, is described.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Apoptosis
Benzene / chemistry
Carbon / chemistry
Catalysis
Cattle
Chemistry, Pharmaceutical / methods
Dimerization
Drug Design
Humans
Models, Chemical
Neovascularization, Pathologic
Receptors, Calcitriol / chemistry
Structure-Activity Relationship
Vitamin D / analogs & derivatives*

Substances

Receptors, Calcitriol
Vitamin D
Carbon
Benzene