A simple method for the quality control of [(18)F]FDG

Appl Radiat Isot. 2010 Sep;68(9):1740-2. doi: 10.1016/j.apradiso.2010.03.006. Epub 2010 Mar 6.

Abstract

Most automated synthesis modules produce [(18)F]FDG within half an hour, but the quality control involving up to three separate methods and three different analytical systems is time consuming. The use of HPLC, TLC, and GC for the quality control of [(18)F]FDG is both time consuming and expensive (high purchase costs). Presented here is a method using a single HPLC system for all three analyses.

MeSH terms

  • Chromatography, High Pressure Liquid / methods*
  • Chromatography, High Pressure Liquid / standards
  • Denmark
  • Drug Stability
  • Fluorodeoxyglucose F18 / analysis
  • Fluorodeoxyglucose F18 / chemistry*
  • Fluorodeoxyglucose F18 / standards*
  • Quality Control
  • Radiopharmaceuticals / analysis
  • Radiopharmaceuticals / chemistry
  • Radiopharmaceuticals / standards

Substances

  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18