Early postoperative detection of tissue necrosis in amputation stumps with indocyanine green fluorescence angiography

Vasc Endovascular Surg. 2010 May;44(4):269-73. doi: 10.1177/1538574410362109. Epub 2010 Mar 30.

Abstract

Objective: Amputations of the lower extremity due to irreversible ischemic tissue loss are performed as distally as possible. Therefore, oftentimes wound-healing disorders develop, requiring additional surgical treatment.

Methods: The amputations stumps of 10 patients with irreversible ischemic tissue loss due to arteriosclerosis were investigated within 72 hours postoperatively with indocyanine green (ICG) fluorescence.

Results: For 6 of the investigated stumps, no perfusion deficit could be seen through fluorescence angiography. All stumps displayed primary healing. In the fluorescence angiography of 3 amputations, stump perfusions deficits predicted later tissue necrosis and had to be amputated again in a second operation. One amputation wound showed a small ICG perfusion deficit that represented a blood clot.

Conclusion: Indocyanine green fluorescence angiography allows a perfusion analysis of amputation stumps and therefore a prediction of the expected tissue necrosis. This tool may allow reliable prediction of amputation level.

MeSH terms

  • Aged
  • Amputation, Surgical / adverse effects*
  • Arterial Occlusive Diseases / complications
  • Arterial Occlusive Diseases / pathology
  • Arterial Occlusive Diseases / physiopathology
  • Arterial Occlusive Diseases / surgery*
  • Early Diagnosis
  • Female
  • Fluorescein Angiography*
  • Fluorescent Dyes*
  • Gangrene
  • Humans
  • Indocyanine Green*
  • Ischemia / etiology
  • Ischemia / pathology
  • Ischemia / physiopathology
  • Ischemia / surgery*
  • Lower Extremity / blood supply*
  • Lower Extremity / pathology
  • Lower Extremity / surgery*
  • Male
  • Necrosis
  • Postoperative Complications / diagnosis*
  • Postoperative Complications / pathology
  • Postoperative Complications / physiopathology
  • Postoperative Complications / surgery
  • Predictive Value of Tests
  • Regional Blood Flow
  • Reoperation
  • Time Factors
  • Treatment Outcome
  • Wound Healing

Substances

  • Fluorescent Dyes
  • Indocyanine Green