Mathematical modeling in bone biology: from intracellular signaling to tissue mechanics

Peter Pivonka; Svetlana V Komarova

doi:10.1016/j.bone.2010.04.601

Mathematical modeling in bone biology: from intracellular signaling to tissue mechanics

Bone. 2010 Aug;47(2):181-9. doi: 10.1016/j.bone.2010.04.601. Epub 2010 Apr 24.

Authors

Peter Pivonka¹, Svetlana V Komarova

Affiliation

¹ Faculty of Engineering, Computing and Mathematics, University of Western Australia, WA 6009, Australia. peter.pivonka@uwa.edu.au

PMID: 20417739
DOI: 10.1016/j.bone.2010.04.601

Abstract

Although conceptual and experimental models are historically well incorporated in bone biology studies, mathematical modeling has been much less-frequently utilized. This review aims to introduce mathematical modeling to readers who are not familiar with the concept underlying this methodology, to outline how mathematical models can help to improve current understanding of bone biology and to discuss examples where mathematical modeling was used to provide new insights into important questions of bone biology.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Bone and Bones / metabolism*
Homeostasis
Humans
Intracellular Space / metabolism*
Models, Biological*
Signal Transduction*

Grants and funding

Canadian Institutes of Health Research/Canada