Abstract
A pair of new isomeric indole alkaloids, naucleaorals A (1) and B (2) were isolated from the roots of Nauclea orientalis. The structures of compounds 1 and 2 were fully characterized using spectroscopic data, and were tested for their cytotoxicity (HeLa and KB cells) and antimalarial activity. Compound 1 showed significant cytotoxicity to HeLa cells with an IC(50) value of 4.0 µg/mL, while compound 2 exhibited very modest cytotoxicity to both cell lines with IC(50) values of 7.8 and 9.5 µg/mL, respectively. Both compounds proved to be inactive in antimalarial assays (IC(50)>10.00 µg/mL).
Copyright © 2010 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Antineoplastic Agents, Phytogenic / therapeutic use*
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Carcinoma, Squamous Cell / drug therapy*
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Female
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HeLa Cells
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Humans
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Indole Alkaloids / chemistry
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Indole Alkaloids / isolation & purification
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Indole Alkaloids / pharmacology
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Indole Alkaloids / therapeutic use*
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KB Cells
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Phytotherapy*
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use*
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Plant Roots
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Rubiaceae / chemistry*
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Uterine Cervical Neoplasms / drug therapy*
Substances
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Antineoplastic Agents, Phytogenic
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Indole Alkaloids
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Plant Extracts
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naucleaoral A
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naucleaoral B