Abstract
Three new aminolipopeptides, designated trichoderins A (1), A1 (2), and B (3), were isolated from a culture of marine sponge-derived fungus of Trichoderma sp. as anti-mycobacterial substances with activity against active and dormant bacilli. The chemical structures of trichoderins were determined on the basis of spectroscopic study. Trichoderins showed potent anti-mycobacterial activity against Mycobacterium smegmatis, Mycobacterium bovis BCG, and Mycobacterium tuberculosis H37Rv under standard aerobic growth conditions as well as dormancy-inducing hypoxic conditions, with MIC values in the range of 0.02-2.0 microg/mL.
Copyright 2010 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Antitubercular Agents
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Humans
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Lipopeptides / isolation & purification
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Lipopeptides / pharmacology*
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Lipopeptides / therapeutic use
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Microbial Sensitivity Tests
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Molecular Structure
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Mycobacterium / drug effects*
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Mycobacterium / growth & development
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Mycobacterium bovis / drug effects
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Mycobacterium smegmatis / drug effects
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Mycobacterium tuberculosis / drug effects
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Porifera / microbiology
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Trichoderma / chemistry*
Substances
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Anti-Bacterial Agents
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Antitubercular Agents
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Lipopeptides
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trichoderin A
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trichoderin A1
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trichoderin B