Anti-Obesity effects of protopanaxdiol types of Ginsenosides isolated from the leaves of American ginseng (Panax quinquefolius L.) in mice fed with a high-fat diet

Rui Liu; JingZhao Zhang; WenCong Liu; Yoshiyuki Kimura; YiNan Zheng

doi:10.1016/j.fitote.2010.07.002

Anti-Obesity effects of protopanaxdiol types of Ginsenosides isolated from the leaves of American ginseng (Panax quinquefolius L.) in mice fed with a high-fat diet

Fitoterapia. 2010 Dec;81(8):1079-87. doi: 10.1016/j.fitote.2010.07.002. Epub 2010 Aug 19.

Authors

Rui Liu¹, JingZhao Zhang, WenCong Liu, Yoshiyuki Kimura, YiNan Zheng

Affiliation

¹ College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun-shi, Jilin 130118, China.

PMID: 20627120
DOI: 10.1016/j.fitote.2010.07.002

Abstract

Effects of protopanaxdiol (PDG) and protopanaxatriol (PTG) types of ginsenosides isolated from the leaves of American ginseng on porcine pancreatic lipase activity were determined in vitro. PDG inhibited the pancreatic lipase activity in a dose-dependent manner at the concentrations of 0.25-1mg/ml. It inhibited hydrolysis of about 83.2% of triolein at about 1mg/ml of PDG. However, PTG showed no inhibitory activity. Therefore, anti-obesity activity of PDG was evaluated in mice fed a high-fat diet. The results demonstrated that PDG was effective in preventing and healing obesity, fatty liver and hypertriglyceridemia in mice fed with a high-fat diet.

MeSH terms

Animals
Anti-Obesity Agents / chemistry
Anti-Obesity Agents / pharmacology
Dietary Fats / adverse effects*
Female
Ginsenosides / chemistry*
Ginsenosides / pharmacology*
Mice
Molecular Structure
Obesity
Panax / chemistry*
Plant Leaves / chemistry
Sapogenins / chemistry*

Substances

Anti-Obesity Agents
Dietary Fats
Ginsenosides
Sapogenins
protopanaxatriol
protopanaxadiol