Designed biodegradable hydrogel structures prepared by stereolithography using poly(ethylene glycol)/poly(D,L-lactide)-based resins

Tetsu M Seck; Ferry P W Melchels; Jan Feijen; Dirk W Grijpma

doi:10.1016/j.jconrel.2010.07.111

Designed biodegradable hydrogel structures prepared by stereolithography using poly(ethylene glycol)/poly(D,L-lactide)-based resins

J Control Release. 2010 Nov 20;148(1):34-41. doi: 10.1016/j.jconrel.2010.07.111. Epub 2010 Jul 24.

Authors

Tetsu M Seck¹, Ferry P W Melchels², Jan Feijen², Dirk W Grijpma³

Affiliations

¹ Institute of Organic Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 10-14, D-55099 Mainz, Germany; MIRA Institute for Biomedical Technology and Technical Medicine, and Department of Biomaterials Science and Technology, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands.
² MIRA Institute for Biomedical Technology and Technical Medicine, and Department of Biomaterials Science and Technology, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands.
³ MIRA Institute for Biomedical Technology and Technical Medicine, and Department of Biomaterials Science and Technology, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands; Department of Biomedical Engineering, University Medical Centre Groningen and University of Groningen, P.O. Box 196, 9700 AD Groningen, The Netherlands. Electronic address: d.w.grijpma@utwente.nl.

PMID: 20659509
DOI: 10.1016/j.jconrel.2010.07.111

Abstract

Designed three-dimensional biodegradable poly(ethylene glycol)/poly(D,L-lactide) hydrogel structures were prepared for the first time by stereolithography at high resolutions. A photo-polymerisable aqueous resin comprising PDLLA-PEG-PDLLA-based macromer, visible light photo-initiator, dye and inhibitor in DMSO/water was used to build the structures. Porous and non-porous hydrogels with well-defined architectures and good mechanical properties were prepared. Porous hydrogel structures with a gyroid pore network architecture showed narrow pore size distributions, excellent pore interconnectivity and good mechanical properties. The structures showed good cell seeding characteristics, and human mesenchymal stem cells adhered and proliferated well on these materials.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biodegradation, Environmental
Cell Adhesion
Humans
Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry*
Mesenchymal Stem Cells
Polyesters / chemistry*
Polyethylene Glycols / chemistry*
Resins, Synthetic / chemistry*

Substances

Polyesters
Resins, Synthetic
Hydrogel, Polyethylene Glycol Dimethacrylate
Polyethylene Glycols
poly(lactide)