Abstract
Myeloid-derived suppressor cells are one of the major factors responsible for immune suppression in cancer. They also contribute to limited efficacy of current vaccination strategies. Here, we give an overview of the myeloid-derived suppressor cells field focusing primarily on the studies in cancer patients and current and future therapeutic options targeting these cells.
MeSH terms
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Animals
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Antigen-Presenting Cells / drug effects
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Antigen-Presenting Cells / microbiology*
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Antigen-Presenting Cells / pathology
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Drug Delivery Systems / methods
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Humans
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Mice
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Myeloid Cells / drug effects
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Myeloid Cells / immunology*
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Myeloid Cells / pathology
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Neoplasms / immunology*
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Neoplasms / pathology
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Neoplasms / therapy
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T-Lymphocytes, Regulatory / immunology