Abstract
A methanolic extract of Agrimonia eupatoria (Rosaceae) significantly attenuated glutamate-induced oxidative stress in HT22 hippocampal cells. A new flavonoid, characterized as kaempferol 3-O-beta-D-(2''-O-acetyl-6''-(E)-p-coumaroyl)-glucopyranoside (2''-acetyl-tiliroside (1), was isolated from the methanolic extract of A. eupatoria stems together with nine known flavonoids. Compounds 4, 7, 8 and 9 all showed a neuroprotective effect on glutamate-induced toxicity in HT22 cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Agrimonia / chemistry*
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Cell Line
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Flavonoids / chemistry
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Flavonoids / isolation & purification
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Flavonoids / pharmacology*
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Glutamic Acid / toxicity*
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Hippocampus / cytology
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Hippocampus / drug effects*
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Hippocampus / metabolism*
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Neuroprotective Agents / chemistry
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Neuroprotective Agents / isolation & purification
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Neuroprotective Agents / pharmacology*
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Oxidative Stress / drug effects*
Substances
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Flavonoids
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Neuroprotective Agents
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Glutamic Acid