Synthesis and antituberculosis activity of some new pyridazine derivatives. Part II

Dorina Mantu; Mihaela Cătălina Luca; Costel Moldoveanu; Gheorghita Zbancioc; Ionel I Mangalagiu

doi:10.1016/j.ejmech.2010.08.029

Synthesis and antituberculosis activity of some new pyridazine derivatives. Part II

Eur J Med Chem. 2010 Nov;45(11):5164-8. doi: 10.1016/j.ejmech.2010.08.029. Epub 2010 Aug 18.

Authors

Dorina Mantu¹, Mihaela Cătălina Luca, Costel Moldoveanu, Gheorghita Zbancioc, Ionel I Mangalagiu

Affiliation

¹ Al. I. Cuza University of Iasi, Organic and Biochemistry Department, Bd. Carol 11, 700506 Iasi, Romania.

PMID: 20813433
DOI: 10.1016/j.ejmech.2010.08.029

Abstract

A series of eighteen novel compounds with pyridazine moiety were synthesized and their in vitro antituberculosis activities have been evaluated. A fast, general, and facile method for preparation of pyridazine derivatives in moderate to excellent yields is presented. Three compounds were found to be moderate active against Mycobacterium tuberculosis. Correlation of structure-biological activity has been done.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antitubercular Agents / chemical synthesis*
Antitubercular Agents / pharmacology*
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Mycobacterium tuberculosis / drug effects
Pyridazines / chemical synthesis*
Pyridazines / pharmacology*
Structure-Activity Relationship

Substances

Antitubercular Agents
Pyridazines
pyridazine