Dihydro-resveratrol--a potent dietary polyphenol

Andrei A Gakh; Natalia Yu Anisimova; Mikhail V Kiselevsky; Sergey V Sadovnikov; Ivan N Stankov; Mikhail V Yudin; Konstantin A Rufanov; Mikhail Yu Krasavin; Andrey V Sosnov

doi:10.1016/j.bmcl.2010.08.002

Dihydro-resveratrol--a potent dietary polyphenol

Bioorg Med Chem Lett. 2010 Oct 15;20(20):6149-51. doi: 10.1016/j.bmcl.2010.08.002. Epub 2010 Aug 5.

Authors

Andrei A Gakh¹, Natalia Yu Anisimova, Mikhail V Kiselevsky, Sergey V Sadovnikov, Ivan N Stankov, Mikhail V Yudin, Konstantin A Rufanov, Mikhail Yu Krasavin, Andrey V Sosnov

Affiliation

¹ Oak Ridge National Laboratory, Oak Ridge, TN 37831-6242, USA. gakhaa@ornl.gov

PMID: 20813524
DOI: 10.1016/j.bmcl.2010.08.002

Abstract

Dihydro-resveratrol (dihydro-R), a prominent polyphenol component of red wine, has a profound proliferative effect on hormone-sensitive tumor cell lines such as breast cancer cell line MCF7. We found a significant increase in MCF7 tumor cells growth rates in the presence of picomolar concentrations of this compound. The proliferative effect of dihydro-R was not observed in cell lines that do not express hormone receptors (MDA-MB-231, BT-474, and К-562).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry*
Antineoplastic Agents, Phytogenic / pharmacology*
Breast Neoplasms / drug therapy
Cell Line, Tumor
Cell Proliferation / drug effects*
Dietary Supplements
Female
Flavonoids / chemistry
Flavonoids / pharmacology
Humans
Neoplasms, Hormone-Dependent / drug therapy
Phenols / chemistry
Phenols / pharmacology
Polyphenols
Resveratrol
Stilbenes / chemistry*
Stilbenes / pharmacology*
Wine

Substances

Antineoplastic Agents, Phytogenic
Flavonoids
Phenols
Polyphenols
Stilbenes
Resveratrol