Cu(I)-catalyzed carboxylative coupling of terminal alkynes, allylic chlorides, and CO2

Wen-Zhen Zhang; Wen-Jie Li; Xiao Zhang; Hui Zhou; Xiao-Bing Lu

doi:10.1021/ol102172v

Cu(I)-catalyzed carboxylative coupling of terminal alkynes, allylic chlorides, and CO2

Org Lett. 2010 Nov 5;12(21):4748-51. doi: 10.1021/ol102172v.

Authors

Wen-Zhen Zhang¹, Wen-Jie Li, Xiao Zhang, Hui Zhou, Xiao-Bing Lu

Affiliation

¹ State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, 116012, China. zhangwz@dlut.edu.cn

PMID: 20929264
DOI: 10.1021/ol102172v

Abstract

A highly selective synthesis of a variety of functionalized allylic 2-alkynoates was realized via the carboxylative coupling of terminal alkynes, allylic chlorides, and CO(2) catalyzed by the N-heterocyclic carbene copper(I) complex (IPr)CuCl. The catalyst can be easily recovered without any loss in activity and product selectivity.