Synthesis of a novel magnetic drug delivery system composed of doxorubicin-conjugated Fe3O4 nanoparticle cores and a PEG-functionalized porous silica shell

Feng-Hua Chen; Li-Ming Zhang; Qing-Tao Chen; Yi Zhang; Zhi-Jun Zhang

doi:10.1039/c0cc02577a

Synthesis of a novel magnetic drug delivery system composed of doxorubicin-conjugated Fe3O4 nanoparticle cores and a PEG-functionalized porous silica shell

Chem Commun (Camb). 2010 Dec 7;46(45):8633-5. doi: 10.1039/c0cc02577a. Epub 2010 Oct 12.

Authors

Feng-Hua Chen¹, Li-Ming Zhang, Qing-Tao Chen, Yi Zhang, Zhi-Jun Zhang

Affiliation

¹ Suzhou Institute of Nano-tech and Nano-bionics, Chinese Academy of Sciences, 398 Ruoshui Road, Suzhou 215125, P. R. China.

PMID: 20941412
DOI: 10.1039/c0cc02577a

Abstract

Coating a layer of PEG functionalized porous silica shell onto doxorubicin-conjugated Fe(3)O(4) nanoparticles, we demonstrated, provides a number of combined advantages in view of the magnetic carrier's therapeutic functionality to treat tumors.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biological Transport
Doxorubicin / chemistry*
Drug Carriers / chemical synthesis*
Drug Carriers / chemistry*
Drug Carriers / metabolism
Drug Design
HeLa Cells
Humans
Magnetics*
Magnetite Nanoparticles / chemistry*
Molecular Imaging
Polyethylene Glycols / chemistry*
Porosity
Silicon Dioxide / chemistry*

Substances

Drug Carriers
Magnetite Nanoparticles
Polyethylene Glycols
Silicon Dioxide
Doxorubicin