Abstract
A microwave-assisted, one-pot, three-step Sonogashira cross-coupling-desilylation-cycloaddition sequence was developed for the convenient preparation of 1,4-disubstituted 1,2,3-triazoles starting from a range of halides, acyl chlorides, ethynyltrimethylsilane, and azides.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Alkynes / chemistry*
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Azides / chemistry*
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Catalysis
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Copper / chemistry*
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Cyclization
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Microwaves
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Molecular Structure
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Silanes / chemistry*
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Triazoles / chemical synthesis*
Substances
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Alkynes
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Azides
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Silanes
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Triazoles
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Copper