Abstract
The human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus discovered to be causative of a human cancer, adult T-cell leukemia. The transforming entity of HTLV-1 has been attributed to the virally-encoded oncoprotein, Tax. Unlike the v-onc proteins encoded by other oncogenic animal retroviruses that transform cells, Tax does not originate from a c-onc counterpart. In this article, we review progress in our understanding of HTLV-1 infectivity, cellular transformation, anti-sense transcription and therapy, 30 years after the original discovery of this virus.
Publication types
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Research Support, N.I.H., Intramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Basic-Leucine Zipper Transcription Factors / genetics
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Basic-Leucine Zipper Transcription Factors / metabolism*
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Cell Transformation, Viral*
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DNA Damage
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DNA Repair
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Genes, pX*
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Human T-lymphotropic virus 1 / genetics
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Human T-lymphotropic virus 1 / metabolism*
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Human T-lymphotropic virus 1 / pathogenicity
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Humans
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Leukemia-Lymphoma, Adult T-Cell / drug therapy*
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Leukemia-Lymphoma, Adult T-Cell / immunology
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Leukemia-Lymphoma, Adult T-Cell / virology*
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Retroviridae Proteins
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Viral Proteins / genetics
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Viral Proteins / metabolism*
Substances
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Basic-Leucine Zipper Transcription Factors
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HBZ protein, human T-cell leukemia virus type I
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Retroviridae Proteins
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Viral Proteins