Label-free electrochemical impedance sensing of DNA hybridization based on functionalized graphene sheets

Chem Commun (Camb). 2011 Feb 14;47(6):1743-5. doi: 10.1039/c0cc04514d. Epub 2010 Dec 1.

Abstract

Negative-charge change and conformation transition upon DNA immobilization and hybridization on functionalized graphene sheets were monitored by the EIS technique and adopted as the signal for label-free electrochemical DNA hybridization detection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Biosensing Techniques / methods*
  • DNA / analysis*
  • DNA / genetics
  • DNA / metabolism
  • Electric Impedance
  • Electrochemistry
  • Electrodes
  • Graphite / chemistry*
  • Microscopy, Electron, Transmission
  • Nucleic Acid Hybridization / methods*
  • Perylene / analogs & derivatives
  • Perylene / chemistry
  • Spectrum Analysis
  • Staining and Labeling

Substances

  • Perylene
  • Graphite
  • DNA