Keeping viruses in Chk: DNA damage signaling puts the brakes on transformation

Caroline E Lilley; Matthew D Weitzman

doi:10.1016/j.chom.2010.11.010

Keeping viruses in Chk: DNA damage signaling puts the brakes on transformation

Cell Host Microbe. 2010 Dec 16;8(6):464-6. doi: 10.1016/j.chom.2010.11.010.

Authors

Caroline E Lilley¹, Matthew D Weitzman

Affiliation

¹ The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. lilley@salk.edu

PMID: 21147460
DOI: 10.1016/j.chom.2010.11.010

Abstract

Oncogenic viruses infect many cells but rarely lead to tumorigenesis. In this issue of Cell Host & Microbe, Nikitin et al. describe how a protective DNA damage response acts to suppress transformation in the majority of cells latently infected with Epstein-Barr virus (EBV).

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