Go6976 abrogates GPVI-mediated platelet functional responses in human platelets through inhibition of Syk

J Thromb Haemost. 2011 Mar;9(3):608-10. doi: 10.1111/j.1538-7836.2011.04192.x.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Blood Platelets / drug effects*
  • Blood Platelets / physiology*
  • Calcium Signaling / drug effects
  • Carbazoles / pharmacology*
  • Carrier Proteins / pharmacology
  • Crotalid Venoms / pharmacology
  • Humans
  • In Vitro Techniques
  • Intracellular Signaling Peptides and Proteins / antagonists & inhibitors*
  • Intracellular Signaling Peptides and Proteins / blood
  • Isoenzymes / antagonists & inhibitors
  • Isoenzymes / blood
  • Lectins, C-Type
  • Peptides / pharmacology
  • Platelet Membrane Glycoproteins / physiology*
  • Protein Kinase C / antagonists & inhibitors
  • Protein Kinase C / blood
  • Protein Kinase Inhibitors / pharmacology
  • Protein-Tyrosine Kinases / antagonists & inhibitors*
  • Protein-Tyrosine Kinases / blood
  • Syk Kinase

Substances

  • Carbazoles
  • Carrier Proteins
  • Crotalid Venoms
  • Intracellular Signaling Peptides and Proteins
  • Isoenzymes
  • Lectins, C-Type
  • Peptides
  • Platelet Membrane Glycoproteins
  • Protein Kinase Inhibitors
  • collagen-related peptide
  • platelet membrane glycoprotein VI
  • Go 6976
  • convulxin
  • Protein-Tyrosine Kinases
  • SYK protein, human
  • Syk Kinase
  • Protein Kinase C