Abstract
The ideal nanoscale drug delivery vehicle allows control over the released dose in space and time. We demonstrate that this can be achieved by stealth liposomes comprising self-assembled superparamagnetic iron oxide nanoparticles (NPs) individually stabilized with palmityl-nitroDOPA incorporated in the lipid membrane. Alternating magnetic fields were used to control timing and dose of repeatedly released cargo from such vesicles by locally heating the membrane, which changed its permeability without major effects on the environment.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Electromagnetic Fields
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Ferric Compounds / chemistry*
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Ferric Compounds / radiation effects
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Liposomes / chemistry*
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Liposomes / radiation effects*
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Materials Testing
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Membranes, Artificial*
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Nanocapsules / chemistry*
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Nanocapsules / radiation effects*
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Permeability / radiation effects
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Pharmaceutical Preparations / administration & dosage
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Pharmaceutical Preparations / chemistry*
Substances
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Ferric Compounds
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Liposomes
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Membranes, Artificial
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Nanocapsules
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Pharmaceutical Preparations
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ferric oxide