T helper (Th)1, Th2, and Th17 interleukin pathways in infertile patients with minimal/mild endometriosis

Carolina Giordani Andreoli; Vanessa Krebs Genro; Carlos Augusto Souza; Tatiana Michelon; João Paolo Bilibio; Camila Scheffel; João Sabino Cunha-Filho

doi:10.1016/j.fertnstert.2011.02.019

T helper (Th)1, Th2, and Th17 interleukin pathways in infertile patients with minimal/mild endometriosis

Fertil Steril. 2011 Jun 30;95(8):2477-80. doi: 10.1016/j.fertnstert.2011.02.019. Epub 2011 Mar 10.

Authors

Carolina Giordani Andreoli¹, Vanessa Krebs Genro, Carlos Augusto Souza, Tatiana Michelon, João Paolo Bilibio, Camila Scheffel, João Sabino Cunha-Filho

Affiliation

¹ Programa de Pós-Graduação em Ciências Médicas, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

PMID: 21392744
DOI: 10.1016/j.fertnstert.2011.02.019

Abstract

In the present study, interleukin (IL)-10, IL-12, IL-17, and IL-23 levels were measured in serum and peritoneal fluid of women with minimal or mild endometriosis and compared with levels in controls without endometriosis. Higher IL-23 levels were encountered in the peritoneal fluid of women with endometriosis, suggesting a possible role of this cytokine in these women's infertility.

MeSH terms

Adult
Ascitic Fluid / immunology*
Biomarkers / blood
Brazil
Case-Control Studies
Cross-Sectional Studies
Endometriosis / complications
Endometriosis / diagnosis
Endometriosis / immunology*
Enzyme-Linked Immunosorbent Assay
Female
Humans
Infertility, Female / diagnosis
Infertility, Female / immunology*
Interleukin-10 / blood
Interleukin-12 / blood
Interleukin-17 / blood
Interleukin-23 / blood*
Laparoscopy
Peritoneal Diseases / complications
Peritoneal Diseases / diagnosis
Peritoneal Diseases / immunology*
Severity of Illness Index
T-Lymphocytes, Helper-Inducer / immunology*
Th1 Cells / immunology
Th17 Cells / immunology
Th2 Cells / immunology
Up-Regulation

Substances

Biomarkers
IL10 protein, human
Interleukin-17
Interleukin-23
Interleukin-10
Interleukin-12