BNCT for locally recurrent head and neck cancer: preliminary clinical experience from a phase I/II trial at Tsing Hua Open-Pool Reactor

L W Wang; S J Wang; P Y Chu; C Y Ho; S H Jiang; Y W H Liu; Y H Liu; H M Liu; J J Peir; F I Chou; S H Yen; Y L Lee; C W Chang; C S Liu; Y W Chen; K Ono

doi:10.1016/j.apradiso.2011.03.008

BNCT for locally recurrent head and neck cancer: preliminary clinical experience from a phase I/II trial at Tsing Hua Open-Pool Reactor

Appl Radiat Isot. 2011 Dec;69(12):1803-6. doi: 10.1016/j.apradiso.2011.03.008. Epub 2011 Mar 30.

Authors

L W Wang¹, S J Wang, P Y Chu, C Y Ho, S H Jiang, Y W H Liu, Y H Liu, H M Liu, J J Peir, F I Chou, S H Yen, Y L Lee, C W Chang, C S Liu, Y W Chen, K Ono

Affiliation

¹ Cancer Center, Taipei Veterans General Hospital, Taiwan, ROC. lwwang@vghtpe.gov.tw

PMID: 21478023
DOI: 10.1016/j.apradiso.2011.03.008

Abstract

To introduce our preliminary experience of treating locally and regionally recurrent Head and Neck cancer patients at Tsing Hua Open-Pool Reactor in Taiwan, four patients (M/F=3/1, median age 68 Y/O) were enrolled. BNCT with BPA (400 mg/kg) injected in 2 phases and prescription dose of 12-35 Gy (Eq.)/fraction for 2 fractions at 30 day interval can be given with sustained blood boron concentration and tolerable early toxicities for recurrent H & N cancer.

Publication types

Clinical Trial, Phase I
Clinical Trial, Phase II

MeSH terms

Aged
Boron Neutron Capture Therapy* / adverse effects
Carcinoma, Squamous Cell / radiotherapy*
Female
Head and Neck Neoplasms / radiotherapy*
Humans
Male
Multimodal Imaging
Neoplasm Recurrence, Local
Positron-Emission Tomography
Taiwan
Tomography, X-Ray Computed