Supramolecular polymeric micelles by the host-guest interaction of star-like calix[4]arene and chlorin e6 for photodynamic therapy

Chem Commun (Camb). 2011 Jun 7;47(21):6063-5. doi: 10.1039/c0cc05662f. Epub 2011 Apr 26.

Abstract

A supramolecular drug delivery system has been developed via the self-assembly of a supramolecular amphiphilic polymer, which is constructed by the host-guest interaction of hydrophilic PEGylated calix[4]arene and hydrophobic photosensitizer chlorin e6. It provides a new strategy for the preparation of supramolecular polymeric micelles, and plays an important role in biological applications.

MeSH terms

  • Calixarenes / chemistry*
  • Calixarenes / therapeutic use
  • Chlorophyllides
  • Female
  • HeLa Cells
  • Humans
  • Micelles*
  • Phenols / chemistry*
  • Phenols / therapeutic use
  • Photochemotherapy
  • Polyethylene Glycols / chemistry
  • Porphyrins / chemistry*
  • Porphyrins / therapeutic use
  • Uterine Cervical Neoplasms / drug therapy

Substances

  • Chlorophyllides
  • Micelles
  • Phenols
  • Porphyrins
  • calix(4)arene
  • Calixarenes
  • Polyethylene Glycols
  • phytochlorin