Copper-catalyzed direct amination of electron-deficient arenes with hydroxylamines

Naoki Matsuda; Koji Hirano; Tetsuya Satoh; Masahiro Miura

doi:10.1021/ol200855t

Copper-catalyzed direct amination of electron-deficient arenes with hydroxylamines

Org Lett. 2011 Jun 3;13(11):2860-3. doi: 10.1021/ol200855t. Epub 2011 May 6.

Authors

Naoki Matsuda¹, Koji Hirano, Tetsuya Satoh, Masahiro Miura

Affiliation

¹ Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka, Japan.

PMID: 21548599
DOI: 10.1021/ol200855t

Abstract

The C-H amination of electron-deficient arenes such as polyfluoroarenes and azole compounds with O-acylated hydroxylamines effectively proceeds in the presence of a copper catalyst even at room temperature to provide the corresponding anilines and aminoazoles in good yields.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amination
Aniline Compounds / chemical synthesis*
Aniline Compounds / chemistry
Catalysis
Copper / chemistry*
Hydroxylamines / chemistry*
Molecular Structure
Oxazoles / chemical synthesis*
Oxazoles / chemistry
Temperature

Substances

Aniline Compounds
Hydroxylamines
Oxazoles
Copper