Metabolic homeostasis: HDACs take center stage

Jason Karpac; Heinrich Jasper

doi:10.1016/j.cell.2011.04.017

Metabolic homeostasis: HDACs take center stage

Cell. 2011 May 13;145(4):497-9. doi: 10.1016/j.cell.2011.04.017.

Authors

Jason Karpac¹, Heinrich Jasper

Affiliation

¹ Department of Biology, University of Rochester, River Campus Box 270211, Rochester, NY 14627, USA.

Abstract

Hormonal regulation of glucose and lipid metabolism is pivotal for metabolic homeostasis and energy balance. Two studies in this issue of Cell (Mihaylova et al., 2011 and Wang et al., 2011) introduce a new conserved signaling mechanism controlling catabolic gene expression: class IIa histone deacetylases (HDACs) regulate Foxo activity in Drosophila and mice.

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