Vitamin C and cellular immune functions. Protection against hypochlorous acid-mediated inactivation of glyceraldehyde-3-phosphate dehydrogenase and ATP generation in human leukocytes as a possible mechanism of ascorbate-mediated immunostimulation

Ann N Y Acad Sci. 1990:587:34-48. doi: 10.1111/j.1749-6632.1990.tb00131.x.
No abstract available

MeSH terms

  • Adenosine Triphosphate / biosynthesis*
  • Antioxidants / pharmacology
  • Ascorbic Acid / pharmacology*
  • Glucose / metabolism
  • Glyceraldehyde 3-Phosphate / metabolism
  • Glyceraldehyde-3-Phosphate Dehydrogenases / antagonists & inhibitors
  • Glyceraldehyde-3-Phosphate Dehydrogenases / metabolism*
  • Humans
  • Hydrogen Peroxide / pharmacology
  • Hypochlorous Acid / antagonists & inhibitors*
  • Hypochlorous Acid / pharmacology
  • Immunity, Cellular / drug effects*
  • Immunity, Cellular / immunology
  • Immunization
  • Lymphocyte Activation / drug effects
  • Mitogens / pharmacology
  • N-Formylmethionine Leucyl-Phenylalanine / pharmacology
  • Neutrophils / drug effects*
  • Neutrophils / immunology
  • Neutrophils / metabolism
  • Sulfhydryl Compounds / metabolism
  • Superoxides / metabolism
  • Tetradecanoylphorbol Acetate / pharmacology

Substances

  • Antioxidants
  • Mitogens
  • Sulfhydryl Compounds
  • Superoxides
  • Glyceraldehyde 3-Phosphate
  • N-Formylmethionine Leucyl-Phenylalanine
  • Hypochlorous Acid
  • Adenosine Triphosphate
  • Hydrogen Peroxide
  • Glyceraldehyde-3-Phosphate Dehydrogenases
  • Glucose
  • Tetradecanoylphorbol Acetate
  • Ascorbic Acid