Abstract
Carcinogenicity of carbon nanotubes is a major concern but has not been well addressed due to the lack of experimental models. Here, we show that chronic exposure to single-walled carbon nanotubes causes malignant transformation of human lung epithelial cells. The transformed cells induce tumorigenesis in mice and exhibit an apoptosis resistant phenotype characteristic of cancer cells. This study provides new evidence for carbon nanotube-induced carcinogenesis and indicates the potential role of p53 in the process.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Apoptosis
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Cell Transformation, Neoplastic / metabolism
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Cell Transformation, Neoplastic / pathology*
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Epithelial Cells / metabolism
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Epithelial Cells / pathology*
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Humans
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Lung / metabolism
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Lung / pathology*
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Mice
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Mice, Nude
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Nanotechnology
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Nanotubes, Carbon / chemistry*
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Particle Size
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Surface Properties
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Tumor Suppressor Protein p53 / metabolism
Substances
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Nanotubes, Carbon
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Tumor Suppressor Protein p53