Concomitant autoimmunity in myasthenia gravis--lack of association with IgA deficiency

J Neuroimmunol. 2011 Jul;236(1-2):118-22. doi: 10.1016/j.jneuroim.2011.05.008. Epub 2011 Jun 12.

Abstract

A marked increase in concomitant autoimmune diseases has previously been noted in patients with myasthenia gravis (MG). We show that these diseases occur both before and after the onset of MG and that the process is not influenced by thymectomy. IgA deficiency (IgAD), which is strongly associated with the same HLA haplotype as early onset MG, has recently been suggested to be an autoimmune disease. However, there was no increase in the prevalence of IgAD in a large cohort of Swedish MG patients.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cohort Studies
  • Haplotypes / genetics
  • Humans
  • IgA Deficiency / genetics*
  • IgA Deficiency / immunology*
  • Middle Aged
  • Myasthenia Gravis / genetics*
  • Myasthenia Gravis / immunology*
  • Polymorphism, Single Nucleotide / genetics
  • Registries