Abstract
A series of four dendrimers end-functionalized with gold(I) has been prepared from alkyne-terminated precursors and (tricyclohexylphosphine)gold(I) azide. Isolated yields range from 84-89%, based on gold. The first-generation dendrimer is cytotoxic toward 3T3 mouse fibroblast cells. Apoptosis ensues within 6 h of treatment with gold(I).
This journal is © The Royal Society of Chemistry 2011
MeSH terms
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3T3 Cells
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Alkynes / chemical synthesis
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Alkynes / chemistry
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Alkynes / pharmacology
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Animals
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Apoptosis / drug effects
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Azides / chemical synthesis
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Azides / chemistry
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Azides / pharmacology
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Cytotoxins / chemical synthesis
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Cytotoxins / chemistry*
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Cytotoxins / pharmacology*
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Dendrimers / chemical synthesis
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Dendrimers / chemistry*
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Dendrimers / pharmacology*
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Mice
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Organogold Compounds / chemical synthesis
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Organogold Compounds / chemistry*
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Organogold Compounds / pharmacology*
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Phosphines / chemical synthesis
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Phosphines / chemistry
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Phosphines / pharmacology
Substances
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Alkynes
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Azides
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Cytotoxins
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Dendrimers
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Organogold Compounds
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Phosphines