Abstract
Dectin-1 is an innate immune pattern recognition receptor (PRR) that, through its ability to bind β-glucans, is involved in the recognition of several pathogenic fungi. Dectin-1 can stimulate a variety of cellular responses via the Syk/CARD9 signalling pathway, including phagocytosis, cytokine production and the respiratory burst. Several advances in our understanding of Dectin-1 immunobiology have been made in recent years, including characterisation of additional signalling pathways and demonstration of its ability to directly induce the development of adaptive immunity. However, the physiological role of many of the functions of this receptor is still unclear. This review aims to provide an update on Dectin-1 and its role within antifungal immune responses, focussing on progress made in the last two years.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Aspergillus fumigatus / immunology
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Aspergillus fumigatus / pathogenicity
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CARD Signaling Adaptor Proteins / metabolism
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Candida albicans / immunology
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Candida albicans / pathogenicity
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Cytokines / immunology
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Genotype
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Host-Pathogen Interactions*
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Humans
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Immunity, Innate
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Intracellular Signaling Peptides and Proteins / metabolism
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Lectins, C-Type
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Membrane Proteins / genetics
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Membrane Proteins / metabolism*
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Mice
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Mycoses / immunology*
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Mycoses / microbiology
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Nerve Tissue Proteins / genetics
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Nerve Tissue Proteins / metabolism*
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Phagocytosis
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Protein-Tyrosine Kinases / metabolism
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Reactive Oxygen Species / metabolism
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Signal Transduction
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Syk Kinase
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T-Lymphocyte Subsets / immunology
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T-Lymphocytes / immunology*
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beta-Glucans / metabolism
Substances
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CARD Signaling Adaptor Proteins
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Cytokines
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Intracellular Signaling Peptides and Proteins
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Lectins, C-Type
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Membrane Proteins
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Nerve Tissue Proteins
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Reactive Oxygen Species
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beta-Glucans
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dectin 1
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Protein-Tyrosine Kinases
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SYK protein, human
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Syk Kinase
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Syk protein, mouse