Total synthesis of NW-G01, a cyclic hexapeptide antibiotic, and 34-epi-NW-G01

Org Lett. 2011 Sep 2;13(17):4700-3. doi: 10.1021/ol201912w. Epub 2011 Aug 2.

Abstract

NW-G01, a cyclic hexapeptide antibiotic, and 34-epi-NW-G01 were synthesized by the highly stereoselective convergent approach for the first time, thereby unambiguously determining the absolute structure of NW-G01.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / chemistry
  • Depsipeptides / chemical synthesis*
  • Depsipeptides / chemistry
  • Molecular Conformation
  • Stereoisomerism

Substances

  • Anti-Bacterial Agents
  • Depsipeptides
  • NW-G01