Lipid arrays identify myelin-derived lipids and lipid complexes as prominent targets for oligoclonal band antibodies in multiple sclerosis

J Neuroimmunol. 2011 Sep 15;238(1-2):87-95. doi: 10.1016/j.jneuroim.2011.08.002. Epub 2011 Aug 26.

Abstract

The presence of oligoclonal bands of IgG (OCB) in cerebrospinal fluid (CSF) is used to establish a diagnosis of multiple sclerosis (MS), but their specificity has remained an enigma since its first description over forty years ago. We now report that the use of lipid arrays identifies heteromeric complexes of myelin derived lipids as a prominent target for this intrathecal B cell response.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • B-Lymphocytes / immunology
  • B-Lymphocytes / metabolism
  • Cells, Cultured
  • Embryo, Mammalian
  • Humans
  • Immunoglobulin G / cerebrospinal fluid*
  • Lipid Metabolism*
  • Multiple Sclerosis* / cerebrospinal fluid
  • Multiple Sclerosis* / immunology
  • Multiple Sclerosis* / pathology
  • Myelin Basic Protein / metabolism
  • Myelin Sheath / immunology
  • Myelin Sheath / metabolism*
  • O Antigens / metabolism
  • Oligoclonal Bands / immunology*
  • Rats
  • Rats, Sprague-Dawley
  • Spinal Cord / cytology

Substances

  • Immunoglobulin G
  • Myelin Basic Protein
  • O Antigens
  • Oligoclonal Bands