Abstract
Sulfated polysaccharide extracted from blue algae Enteromorpha linza is proved to possess excellent antioxidant activities. Two derivatives by means of oversulfated and acetylated coupling were synthesized and investigated their antioxidant activities including scavenging effect of superoxide, hydroxyl and 1,1-diphenyl-2-picrylhydrazyl radicals. And then the relationship between antioxidant activity and chemical characteristics was characterized. The results of chemical analysis and FT-IR showed that the modification of polysaccharide was successful. In addition, it was found that certain derivatives exhibited stronger antioxidant activity than raw material. They could serve as free-radical inhibitors or scavengers, acting possibly as primary antioxidants.
Copyright © 2011 Elsevier B.V. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Acetylation
-
Biphenyl Compounds / antagonists & inhibitors
-
Biphenyl Compounds / metabolism
-
Chemistry, Pharmaceutical / methods*
-
Free Radical Scavengers / chemistry
-
Free Radical Scavengers / isolation & purification*
-
Free Radical Scavengers / pharmacology
-
Free Radicals / antagonists & inhibitors
-
Free Radicals / metabolism
-
Hydroxyl Radical / antagonists & inhibitors
-
Hydroxyl Radical / metabolism
-
Oxidation-Reduction / drug effects
-
Picrates / antagonists & inhibitors
-
Picrates / metabolism
-
Plant Extracts / chemistry*
-
Polysaccharides / chemistry
-
Polysaccharides / isolation & purification*
-
Polysaccharides / pharmacology
-
Solutions
-
Spectroscopy, Fourier Transform Infrared
-
Structure-Activity Relationship
-
Sulfates / chemistry
-
Superoxides / antagonists & inhibitors
-
Superoxides / metabolism
-
Ulva / chemistry*
Substances
-
Biphenyl Compounds
-
Free Radical Scavengers
-
Free Radicals
-
Picrates
-
Plant Extracts
-
Polysaccharides
-
Solutions
-
Sulfates
-
Superoxides
-
Hydroxyl Radical
-
1,1-diphenyl-2-picrylhydrazyl