Abstract
Dual infection of 26 fetal and neonatal small ruminants with border disease virus (BDV) and peste des petits ruminants virus (PPRV) is reported. The animals included five aborted lamb fetuses, 19 neonatal lambs and two neonatal kids from flocks in regions of the Black Sea and the Aegean region. BDV and PPRV antigens were detected immunohistochemically in the brain, oral mucosa, intestine and lung of infected animals. Reverse transcriptase-polymerase chain reaction was used to demonstrate PPRV and BDV in samples of the spleen, lymph node, lung and brain from infected animals. On the basis of observations made, it is concluded that brain damage following intrauterine infection with BDV facilitates the passage of PPRV to the brain and results in infection of neuronal and glial cells by PPRV.
Copyright © 2011 Elsevier Ltd. All rights reserved.
MeSH terms
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Animals
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Animals, Newborn
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Antigens, Viral / immunology
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Border Disease / congenital
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Border Disease / pathology
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Border Disease / virology*
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Border disease virus / genetics
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Border disease virus / immunology
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Border disease virus / isolation & purification*
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Brain Diseases / pathology
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Brain Diseases / veterinary*
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Brain Diseases / virology
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Female
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Immunoenzyme Techniques / veterinary
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Peste-des-Petits-Ruminants / pathology
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Peste-des-Petits-Ruminants / veterinary*
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Peste-des-Petits-Ruminants / virology
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Peste-des-petits-ruminants virus / isolation & purification*
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Peste-des-petits-ruminants virus / physiology
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Phylogeny
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Pregnancy
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Pregnancy Complications, Infectious / veterinary
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RNA, Viral / analysis
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Reverse Transcriptase Polymerase Chain Reaction / veterinary
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Sheep
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Sheep Diseases / pathology
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Sheep Diseases / virology*
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Viral Tropism / physiology*
Substances
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Antigens, Viral
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RNA, Viral