Abstract
Aztreonam/metronidazole and cefotaxime/metronidazole were compared in a prospective trial in 154 patients undergoing elective colorectal surgery. Three antibiotic doses were given over 16 hours. A significant excess of wound sepsis in the aztreonam group was seen (23/71 vs 9/70 chi 2 6.60; P less than 0.01). Sepsis was almost invariably due to Gram-positive organisms and, in particular, Staphylococcus aureus.
Publication types
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Clinical Trial
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Comparative Study
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Multicenter Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Aztreonam / therapeutic use*
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Bacterial Infections / prevention & control*
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Cefotaxime / therapeutic use*
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Colon / surgery*
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Drug Therapy, Combination / therapeutic use
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Gram-Positive Bacteria / drug effects
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Humans
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Metronidazole / therapeutic use*
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Multicenter Studies as Topic
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Postoperative Complications / prevention & control*
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Randomized Controlled Trials as Topic
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Rectum / surgery*
Substances
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Metronidazole
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Aztreonam
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Cefotaxime