Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naïve/memory Breg ratio during a relapse but not in remission

Stephanie Knippenberg; Evelyn Peelen; Joost Smolders; Mariëlle Thewissen; Paul Menheere; Jan Willem Cohen Tervaert; Raymond Hupperts; Jan Damoiseaux

doi:10.1016/j.jneuroim.2011.08.019

Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naïve/memory Breg ratio during a relapse but not in remission

J Neuroimmunol. 2011 Oct 28;239(1-2):80-6. doi: 10.1016/j.jneuroim.2011.08.019. Epub 2011 Sep 21.

Authors

Stephanie Knippenberg¹, Evelyn Peelen, Joost Smolders, Mariëlle Thewissen, Paul Menheere, Jan Willem Cohen Tervaert, Raymond Hupperts, Jan Damoiseaux

Affiliation

¹ School for Mental Health and Neuroscience, Maastricht University Medical Center, Universiteitssingel 50, Maastricht,The Netherlands. S.Knippenberg@maastrichtuniversity.nl

PMID: 21940055
DOI: 10.1016/j.jneuroim.2011.08.019

Abstract

In this study, we assessed B cell subsets, including Bregs, during stable and active disease in relapsing remitting multiple sclerosis (RRMS) patients and related B cell subsets to vitamin D status. We report that RRMS patients have a decreased percentage of both memory B cells and Bregs compared to healthy controls. During a relapse, the reduction in Bregs involved in particular naïve Bregs. We found no correlation between vitamin D status and B cell subsets. An effect of vitamin D on Bregs cannot be ruled out, since it might be the function that is interfered with instead of relative numbers.

Publication types

Comparative Study

MeSH terms

Adult
B-Lymphocyte Subsets / immunology
B-Lymphocyte Subsets / metabolism
B-Lymphocyte Subsets / pathology
B-Lymphocytes, Regulatory / immunology*
B-Lymphocytes, Regulatory / metabolism
B-Lymphocytes, Regulatory / pathology*
Cells, Cultured
Female
Humans
Immunologic Memory / immunology*
Interleukin-10 / antagonists & inhibitors*
Interleukin-10 / biosynthesis*
Interleukin-10 / metabolism
Lymphocyte Activation / immunology
Lymphocyte Count
Lymphopenia / diagnosis
Lymphopenia / immunology
Lymphopenia / pathology
Male
Middle Aged
Multiple Sclerosis, Relapsing-Remitting / diagnosis
Multiple Sclerosis, Relapsing-Remitting / immunology*
Multiple Sclerosis, Relapsing-Remitting / pathology*
Resting Phase, Cell Cycle / immunology*
Toll-Like Receptor 9 / antagonists & inhibitors
Toll-Like Receptor 9 / biosynthesis
Vitamin D / analogs & derivatives
Vitamin D / blood

Substances

IL10 protein, mouse
TLR9 protein, human
Toll-Like Receptor 9
Interleukin-10
Vitamin D
25-hydroxyvitamin D