Fusion proteins between ligands for NKG2D and CD20-directed single-chain variable fragments sensitize lymphoma cells for natural killer cell-mediated lysis and enhance antibody-dependent cellular cytotoxicity

Leukemia. 2012 Apr;26(4):830-4. doi: 10.1038/leu.2011.288. Epub 2011 Oct 18.

Authors

C Kellner, D Hallack, P Glorius, M Staudinger, S Mohseni Nodehi, M de Weers, J G J van de Winkel, P W H I Parren, M Stauch, T Valerius, R Repp, A Humpe, M Gramatzki, M Peipp

PMID: 22005785
DOI: 10.1038/leu.2011.288

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

ADP-ribosyl Cyclase 1 / metabolism
Antibody-Dependent Cell Cytotoxicity*
Antigens, CD20 / metabolism
Cytotoxicity, Immunologic*
GPI-Linked Proteins / therapeutic use
Histocompatibility Antigens Class I / therapeutic use*
Humans
Intercellular Signaling Peptides and Proteins / therapeutic use*
Killer Cells, Natural / immunology*
Ligands
Lymphoma / drug therapy*
Lymphoma / immunology
NK Cell Lectin-Like Receptor Subfamily K / metabolism
Recombinant Fusion Proteins / therapeutic use*

Substances

Antigens, CD20
GPI-Linked Proteins
Histocompatibility Antigens Class I
Intercellular Signaling Peptides and Proteins
KLRK1 protein, human
Ligands
MHC class I-related chain A
NK Cell Lectin-Like Receptor Subfamily K
Recombinant Fusion Proteins
ULBP2 protein, human
ADP-ribosyl Cyclase 1