Abstract
We evaluated the in vivo antischistosomal activities of 11 structurally diverse synthetic peroxides. Of all compounds tested, ozonide (1,2,4-trioxolane) OZ418 had the highest activity against adult Schistosoma mansoni, with total and female worm burden reductions of 80 and 90% (P < 0.05), respectively. Furthermore, treatment of S. haematobium-infected mice with OZ418 reduced the total worm burden by 86%. In conclusion, OZ418 is a promising antischistosomal lead compound.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthelmintics / administration & dosage
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Anthelmintics / chemistry
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Anthelmintics / therapeutic use*
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Female
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Heterocyclic Compounds / administration & dosage
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Heterocyclic Compounds / chemistry
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Heterocyclic Compounds / therapeutic use*
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Mice
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Schistosoma haematobium / drug effects*
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Schistosoma mansoni / drug effects*
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Schistosomiasis haematobia / drug therapy*
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Schistosomiasis haematobia / parasitology
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Schistosomiasis mansoni / drug therapy*
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Schistosomiasis mansoni / parasitology
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Treatment Outcome
Substances
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1,2,4-trioxane
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Anthelmintics
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Heterocyclic Compounds