Abstract
Many children with Autism Spectrum Diseases (ASD) present with seizure activity, but the pathogenesis is not understood. Recent evidence indicates that neuro-inflammation could contribute to seizures. We hypothesize that brain mast cell activation due to allergic, environmental and/or stress triggers could lead to focal disruption of the blood-brain barrier and neuro-inflammation, thus contributing to the development of seizures. Treating neuro-inflammation may be useful when anti-seizure medications are ineffective.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Autistic Disorder / complications*
-
Autistic Disorder / immunology
-
Autistic Disorder / physiopathology
-
Blood-Brain Barrier / pathology*
-
Brain / immunology*
-
Brain / pathology
-
Brain / physiopathology
-
Humans
-
Hypersensitivity / complications
-
Hypersensitivity / immunology
-
Inflammation / complications*
-
Inflammation / pathology
-
Inflammation / physiopathology
-
Seizures / complications*
-
Seizures / immunology
-
Seizures / physiopathology