Mimicking an antimicrobial peptide polymyxin B by use of cyclodextrin

Hatsuo Yamamura; Ken Suzuki; Kazuma Uchibori; Atsushi Miyagawa; Masao Kawai; Chie Ohmizo; Takashi Katsu

doi:10.1039/c1cc16369h

Mimicking an antimicrobial peptide polymyxin B by use of cyclodextrin

Chem Commun (Camb). 2012 Jan 21;48(6):892-4. doi: 10.1039/c1cc16369h. Epub 2011 Dec 5.

Authors

Hatsuo Yamamura¹, Ken Suzuki, Kazuma Uchibori, Atsushi Miyagawa, Masao Kawai, Chie Ohmizo, Takashi Katsu

Affiliation

¹ Graduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, Japan. yamamura.hatsuo@nitech.ac.jp

PMID: 22143262
DOI: 10.1039/c1cc16369h

Abstract

Cyclodextrin derivatives prepared to mimic a membrane active antibacterial peptide polymyxin B strongly permeabilized bacterial membrane and inhibited bacterial proliferation.

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Cell Membrane Permeability / drug effects
Cyclodextrins / chemistry
Cyclodextrins / pharmacology*
Escherichia coli / drug effects*
Escherichia coli / metabolism
Microbial Sensitivity Tests
Polymyxin B / analogs & derivatives
Polymyxin B / chemistry
Polymyxin B / pharmacology*
Potassium / metabolism
Staphylococcus aureus / drug effects*
Staphylococcus aureus / metabolism

Substances

Anti-Bacterial Agents
Cyclodextrins
polymyxin B nonapeptide
Polymyxin B
Potassium