Clicking 1,2,4,5-tetrazine and cyclooctynes with tunable reaction rates

Chem Commun (Camb). 2012 Feb 7;48(12):1736-8. doi: 10.1039/c2cc16716f. Epub 2011 Dec 12.

Abstract

Substituted tetrazines have been found to undergo facile inverse electron demand Diels-Alder reactions with "tunable" reaction rates.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemical synthesis
  • Alkynes / chemistry*
  • Cyclization
  • Heterocyclic Compounds / chemical synthesis
  • Heterocyclic Compounds / chemistry*
  • Kinetics

Substances

  • Alkynes
  • Heterocyclic Compounds