Abstract
A method for five- and six-membered heterocycle formation by palladium-catalyzed C-H/N-H coupling is presented. The method employs a picolinamide directing group, PhI(OAc)(2) oxidant, and toluene solvent at 80-120 °C. Cyclization is effective for sp(2) as well as aliphatic and benzylic sp(3) C-H bonds.
© 2011 American Chemical Society
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Carbon / chemistry*
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Catalysis
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Chemistry Techniques, Synthetic / methods*
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Heterocyclic Compounds / chemical synthesis*
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Heterocyclic Compounds / chemistry*
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Hydrogen / chemistry*
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Nitrogen / chemistry*
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Palladium / chemistry
Substances
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Heterocyclic Compounds
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Palladium
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Carbon
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Hydrogen
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Nitrogen