Abstract
Two new phenolic glycosides, kaempferiaosides A and B were isolated from the rhizomes of Kaempferia parviflora (Zingiberaceae) together with 24 known compounds. Their structures including absolute stereochemistry were elucidated on the basis of chemical and spectroscopic evidence. Among the isolates, 5,3'-dihydroxy-3,7,4'-trimethoxyflavone showed higher activity than silybin, a commercial hepatoprotective agent.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cells, Cultured
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Glycosides / chemistry*
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Glycosides / isolation & purification
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Glycosides / pharmacology
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Hepatocytes / drug effects*
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Magnetic Resonance Spectroscopy
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Mice
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Molecular Conformation
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Phenols / chemistry*
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Phenols / isolation & purification
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Phenols / pharmacology*
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Protective Agents / chemistry*
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Protective Agents / isolation & purification
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Protective Agents / pharmacology*
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Rhizome / chemistry
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Zingiberaceae / chemistry*
Substances
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Glycosides
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Phenols
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Protective Agents
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kaempferiaoside A
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kaempferiaoside B