Overreliance on the hexon gene, leading to misclassification of human adenoviruses

J Virol. 2012 Apr;86(8):4693-5. doi: 10.1128/JVI.06969-11. Epub 2012 Feb 1.

Abstract

The genome of human adenovirus (HAdV) D30 was sequenced in depth. Sequence assembly and analysis revealed two distinct viral sequences with identical hexon genes, which were the same as the one previously reported for HAdV-D30. However, one of the two viruses was found to be a recombinant of HAdV-D29. Exclusive reliance on serum neutralization can lead to mischaracterization of adenoviruses and miss coinfections. Whole-genome sequencing remains the gold standard for proper classification of HAdVs.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoviruses, Human / classification*
  • Adenoviruses, Human / genetics
  • Capsid Proteins / genetics*
  • Cell Line
  • Computational Biology / methods
  • Genome, Viral
  • Humans
  • Molecular Sequence Data
  • Phylogeny
  • Sequence Analysis, DNA

Substances

  • Capsid Proteins
  • hexon capsid protein, Adenovirus

Associated data

  • GENBANK/JN226755
  • GENBANK/JN935766