Abstract
We report here on the first identification of Shigella flexneri subserotype 1c in China. We also report the emergence of resistance to ciprofloxacin and third-generation cephalosporins in this subserotype 1c for the first time. Isolates of seven strains circulating in China yielded three new sequence types and seven pulsed-field gel electrophoresis patterns, thus demonstrating the existence of high genetic diversity within the isolates. Overall, the seven isolates showed reduced susceptibility to ciprofloxacin; one isolate was ciprofloxacin resistant, whilst another developed resistance to ciprofloxacin, norfloxacin, cefotaxime and ceftriaxone.
© 2012 The Authors. Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cephalosporins / pharmacology*
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China / epidemiology
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Communicable Diseases, Emerging / drug therapy
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Communicable Diseases, Emerging / microbiology
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Diarrhea / microbiology
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Drug Resistance, Multiple, Bacterial*
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Dysentery, Bacillary / drug therapy*
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Dysentery, Bacillary / epidemiology
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Dysentery, Bacillary / microbiology
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Electrophoresis, Gel, Pulsed-Field
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Feces / microbiology
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Fluoroquinolones / pharmacology*
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Genetic Variation
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Humans
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Microbial Sensitivity Tests
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Multilocus Sequence Typing
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Nalidixic Acid / pharmacology
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Serotyping
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Shigella flexneri / drug effects
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Shigella flexneri / genetics
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Shigella flexneri / isolation & purification*
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Shigella flexneri / pathogenicity
Substances
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Cephalosporins
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Fluoroquinolones
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Nalidixic Acid