HDAC6 at the Intersection of Neuroprotection and Neurodegeneration

Traffic. 2012 Jun;13(6):771-9. doi: 10.1111/j.1600-0854.2012.01347.x. Epub 2012 Mar 26.

Abstract

Histone deacetylase 6 (HDAC6) catalyzes multiple reactions. We summarize the current knowledge on HDAC6, its targets and functions. Among others, HDAC6 recognizes damaged proteins and assures that these proteins are destroyed by autophagy. On the other hand, HDAC6 also modifies the tracks used by the clearance mechanism so that axonal transport becomes less efficient. We hypothesize that a disturbance in the equilibrium between the different functions of HDAC6 could play an important role in neurodegeneration.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetylation
  • Animals
  • Autophagy
  • Cytoskeleton / metabolism
  • Gene Expression Regulation, Enzymologic*
  • Histone Deacetylase 6
  • Histone Deacetylases / metabolism*
  • Humans
  • Microtubules / metabolism
  • Models, Biological
  • Models, Genetic
  • Neurodegenerative Diseases / metabolism*
  • Neuroprotective Agents / pharmacology
  • Protein Binding
  • Protein Conformation
  • Ubiquitin / metabolism

Substances

  • Neuroprotective Agents
  • Ubiquitin
  • HDAC6 protein, human
  • Histone Deacetylase 6
  • Histone Deacetylases